BRCA1 at a branch point

BRCA1 at a branch point.

T breastand ovarian-specific tumor suppressor protein, BRCA1, has been implicated in regulating the nuclear processes of repair of damaged DNA, chromatin remodeling, and transcription. Although many have sought specific DNA sequences bound by BRCA1, no such sequences have been reported. In new research described in this issue of PNAS (1), BRCA1 protein is shown to bind to DNA with high affinity...

At a New Branch Point

Intelligence at a New Branch Point

Aisb50: Artificial Intelligence at a New Branch Point

It should be noted that from now on ‘the system’ means not the nervous system but the whole complex of the organism and the environment. Thus, if it should be shown that ‘the system’ has some property, it must not be assumed that this property is attributed to the nervous system: it belongs to the whole; and detailed examination may be necessary to ascertain the contributions of the separate pa...

A Bisection-Like Algorithm for Branch Switching at a Simple Branch Point

At a Simple Branch Point x0 of a parameter-dependent nonlinear system, two distinct solutions branches S1 and S2 intersect. A popular method of branch switching from S1 to S2 at x0 is to use an orthogonal vector to the tangent vector to S1at x0 as an initial guess for the tangent vector to S2 at x0. We describe an improved version of this method using a bisection-like procedure, which is especi...